# Kisspeptin Philippines: Reproductive Hormone Research Source: https://www.philippinespeptides.com/peptides/kisspeptin Updated: 2026-09-24 > Kisspeptin in the Philippines: the KISS1 neuropeptide that regulates GnRH release. What human studies in men and women measured, and side effects described. On this page - [What is Kisspeptin](#what) - [How it works](#how) - [Kisspeptin in the Philippines](#ph-context) - [Benefits studied](#benefits) - [Side effects reported](#side-effects) - [Regulatory status](#regulatory) - [Who should not use Kisspeptin](#contraindications) - [FAQ](#faq) - [Where to get Kisspeptin in the Philippines](#sourcing) - [Primary sources](#sources) Hormones and libido · Compound # Kisspeptin Philippines Peptides editorial desk Updated 24 September 2026 Trial data checked 23 September 2026 5 min read 5 sources **Class** - Hormones / Reproductive Kisspeptin is not yet in the evidence datasets this site draws on, so this page makes no claim about what it does. ## What is Kisspeptin Kisspeptin (also called metastin) is a naturally occurring neuropeptide encoded by the KISS1 gene. According to a 2012 review of kisspeptin physiology (Pinilla et al., Physiol Rev), it acts on the kisspeptin receptor (KISS1R, also called GPR54) to drive release of gonadotropin-releasing hormone (GnRH), which in turn drives release of LH (luteinizing hormone) and FSH (follicle-stimulating hormone) from the pituitary. Browse the full [peptide library](https://www.philippinespeptides.com/peptides) for related hormone compounds. Kisspeptin is not in the evidence datasets this site draws on. The human studies cited on this page measured hormone and brain responses in healthy volunteers: kisspeptin-54 stimulated the hypothalamic-pituitary-gonadal axis in men (Dhillo et al., 2005), a single injection of kisspeptin-54 temporarily increased LH pulsatility in healthy women (Jayasena et al., 2013), and kisspeptin modulated sexual and emotional brain processing in a human study (Comninos et al., 2017). ## How it works KISS1R activation: according to the 2012 Pinilla review, kisspeptin binds KISS1R on GnRH neurons in the hypothalamus and triggers GnRH secretion. Pituitary hormones: GnRH reaches the anterior pituitary and stimulates LH and FSH release, which act on the testes and ovaries, as set out in the same review. In a human study in men, kisspeptin-54 stimulated this hypothalamic-pituitary-gonadal axis (Dhillo et al., 2005). ## Kisspeptin in the Philippines A search of the FDA Philippines registered drug products database on 7 May 2026, listed in the sources below, found no Philippine drug registration for kisspeptin. The regulatory dataset this site draws on has no row for kisspeptin, so this page has no later check to report. ## Benefits studied Kisspeptin is not yet in the evidence datasets this site draws on, so this page makes no claim about what it does. Anything published about it elsewhere should be read with its evidence level in mind: most peptides in this category have animal or cell data only. ## Side effects reported No controlled human data on adverse events for Kisspeptin is in the datasets this site draws on, so its safety in people is unknown rather than established. Effects commonly described for it are listed below; how often they occur has not been measured in a controlled trial. - Testicular ache - Increased libido - Nausea - Injection site reactions - Hormone fluctuations - Headache - Reduced response with continuous exposure (theoretical) ## Regulatory status The regulatory dataset this site draws on has no row for Kisspeptin. ## Who should not use Kisspeptin Do not use if - Hormone-sensitive cancers (prostate, ovarian, breast) - Active reproductive hormone disorders - Pregnancy - Under 18 years old - Currently trying to conceive Everything above is research framing. If you have got as far as wanting a vial, the catalogue at Primara Labs, our partner and supplier, is the shortest way to see what is held inside the Philippines and at what price. [View the Primara Labs catalogue](https://www.primaralabs.com/marketplace?utm_source=philippinespeptides&utm_medium=referral&utm_campaign=inline) ## FAQ ### What evidence exists for kisspeptin? Kisspeptin is not in the evidence datasets this site draws on. The sources on this page are three human studies and one review: a 2005 study of kisspeptin-54 in men, a 2013 study of a single kisspeptin-54 injection in healthy women, a 2017 study of brain processing, and a 2012 review of kisspeptin physiology. They measured hormone and brain responses, not treatment outcomes. ### What did the kisspeptin study in men find? In a 2005 human study by Dhillo and colleagues, kisspeptin-54 stimulated the hypothalamic-pituitary-gonadal axis in men. ### Has kisspeptin been studied in women? Yes, in a small number of human studies. In a 2013 study by Jayasena and colleagues, a single injection of kisspeptin-54 temporarily increased LH pulsatility in healthy women. ## Where to get Kisspeptin in the Philippines Primara Labs, our partner and supplier, lists their current vials on the catalogue. Prices and stock change, so check there for what is available now. [View the Primara Labs catalogue](https://www.primaralabs.com/marketplace?utm_source=philippinespeptides&utm_medium=referral&utm_campaign=inline) Our partner and supplier ### Sourcing peptides in the Philippines Primara Labs, our partner and supplier, ships from inventory already inside the Philippines, so there is no customs leg: vials are batch-numbered, Metro Manila orders dispatch same day, the rest of the country lands in 1 to 5 business days, and the store lists 10% off every order. The current list sits on one page, and anything you cannot see on it goes through the same WhatsApp thread. The supply index covers what to ask a seller before paying, and why quoted prices vary so widely. [View Supply Index](https://www.philippinespeptides.com/supply) ## Primary sources Citations supporting the clinical claims on this page. Each entry links to the primary record. - 1. Kisspeptin-54 in human males, Dhillo 2005 Trial Dhillo WS, Chaudhri OB, Patterson M, et al. "Kisspeptin-54 stimulates the hypothalamic-pituitary-gonadal axis in human males." J Clin Endocrinol Metab 2005;90(12):6609–6615. [DOI: 10.1210/jc.2005-1468](https://doi.org/10.1210/jc.2005-1468) - 2. Kisspeptin-54 LH pulsatility in women, Jayasena 2013 Trial Jayasena CN, Comninos AN, Veldhuis JD, et al. "A single injection of kisspeptin-54 temporarily increases luteinizing hormone pulsatility in healthy women." Clin Endocrinol 2013;79(4):558–563. [DOI: 10.1111/cen.12179](https://doi.org/10.1111/cen.12179) - 3. Kisspeptin physiology review, Pinilla 2012 Review Pinilla L, Aguilar E, Dieguez C, et al. "Kisspeptins and reproduction: physiological roles and regulatory mechanisms." Physiol Rev 2012;92(3):1235–1316. [DOI: 10.1152/physrev.00037.2010](https://doi.org/10.1152/physrev.00037.2010) - 4. Kisspeptin and emotional brain processing, Comninos 2017 Trial Comninos AN, Wall MB, Demetriou L, et al. "Kisspeptin modulates sexual and emotional brain processing in humans." J Clin Invest 2017;127(2):709–719. [DOI: 10.1172/JCI89519](https://doi.org/10.1172/JCI89519) - 5. FDA Philippines drug registry: kisspeptin not listed Reference FDA Philippines Registered Drug Products Database. Verified 2026-05-07: kisspeptin has no Philippine drug registration; clomiphene and hCG registered separately for distinct fertility indications. [Source](https://verification.fda.gov.ph/) How this was gathered Findings, evidence levels and sources are from the Research Desk datasets published by [Primara Labs, our partner and supplier](https://www.primaralabs.com/research/evidence?utm_source=philippinespeptides&utm_medium=referral&utm_campaign=inline), synced 23 September 2026 and summarised here in this site’s own words. Risk · Disclosure · Editorial Status This page is editorial information for adults researching peptide therapy. It is not medical advice, not a prescription, and not an endorsement of any specific product, supplier, or protocol. Side effects can be serious and individual response varies. Talk to a licensed physician (ideally one with peptide-specific clinical experience) before starting any compound, adjusting a dose, or discontinuing therapy. In the Philippines, GLP-1 medications are prescription-only under FDA Philippines regulation. Research-grade peptides occupy a regulatory gray area: import for personal research use is generally tolerated, but the Bureau of Customs reserves the right to inspect and detain shipments. Do not import for resale. **Editorial Status** - Non-clinical **Affiliation** - Not a clinic · Not a pharmacy **Last Updated** - September 24, 2026 ### Related peptides - [Compound Melanotan II](https://www.philippinespeptides.com/peptides/melanotan-2) - [Compound CJC-1295 (DAC)](https://www.philippinespeptides.com/peptides/cjc1295-dac) - [Compound Ipamorelin](https://www.philippinespeptides.com/peptides/ipamorelin) - [Compound Epitalon](https://www.philippinespeptides.com/peptides/epitalon) --- Philippines Peptides sells nothing. Primara Labs is our partner and supplier. This is general information, not medical or legal advice.