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Recovery · Compound

TB-500

Synthetic peptide related to thymosin beta-4, identified in the analytical literature as the fragment Ac-LKKTETQ and studied in animal and cell work for wound, corneal and tendon healing.
Video guide: TB-500 in the Philippines: Evidence, Status, Sourcing (2:11)
Video transcript

Searched TB-500 in the Philippines? Here is what it is, and what the evidence shows. TB-500 is related to thymosin beta-4, a 43-amino-acid protein that binds actin in cells. But the literature identifies TB-500 as just 7 of those amino acids: the fragment Ac-LKKTETQ. One caution. Our partner and supplier's catalogue listed the full 43-residue sequence, so identity details are withheld until the supplier confirms the molecule. The evidence is rated animal and cell. No completed human randomised trial has been identified for the fragment, and one is recruiting. In aged and diabetic mice, the fragment promoted skin wound repair about as well as the full protein. In a 2024 cell test, the activity came from a breakdown product, not TB-500 itself. Full-length thymosin beta-4 is a different molecule, with 10 completed human trials, mostly as eye drops. The guide lists fatigue, headache, injection site reactions and lightheadedness as common side effects. FDA Philippines status could not be established: its verification portal timed out. The US FDA has no approved application on record. Our partner and supplier, Primara Labs, lists TB-500 10 mg at ₱2,390, or ₱1,458 per vial in a 10 pack. Research use only. BPC-157, a different molecule, is 20 mg at the same price. Every order includes bacteriostatic water, insulin syringes and alcohol pads, with same-day Metro Manila delivery when you order by noon on a weekday. There is a 60-day money-back guarantee: if an accredited independent laboratory reports the vial is not the compound on the label, Primara refunds what you paid. Read the full guide on Philippines Peptides, then see TB-500 at Primara Labs and order on WhatsApp.

The strongest evidence found for TB-500 comes from animal and cell studies, and every finding below carries its evidence level.

What is TB-500

TB-500 is a synthetic peptide related to thymosin beta-4 (Tβ4), a 43-amino-acid protein and the main actin-sequestering molecule in cells. The analytical literature identifies TB-500 as the acetylated fragment Ac-LKKTETQ, the central actin-binding sequence of thymosin beta-4, rather than the full-length protein (Esposito et al., Drug Test Anal 2012). Browse the full peptide library for related compounds.

The two molecules have different evidence. The TB-500 fragment has animal and cell data only: no completed human randomised controlled trial has been identified for it, and one human trial is recruiting. Full-length thymosin beta-4 has human trials, mostly as eye drops; two phase 3 dry-eye trials posted near-identical results in both arms, and a small phase 3 corneal trial stopped early without a significant result.

Identity note from the research dataset of our partner and supplier: The catalogue listed the full 43-residue thymosin beta-4 sequence under the name TB-500, while the analytical literature identifies TB-500 as the fragment Ac-LKKTETQ, and the catalogue's formula matched neither PubChem record. Identity fields are withheld until the supplier confirms which molecule the vial contains.

How it works

Actin binding: thymosin beta-4 binds actin, and its central sequence LKKTETQ is reported in animal and cell studies to promote cell migration, new blood vessel growth and wound healing.

Wound repair in animals: in aged and diabetic mice, the seven-amino-acid fragment LKKTETQ promoted skin wound repair about as well as the full-length protein (Wound Repair Regen 2003).

Breakdown product: a 2024 cell study found that wound-healing activity in a scratch-wound test came from a TB-500 breakdown product, Ac-LKKTE, while TB-500 itself did not show it (J Chromatogr B 2024).

Benefits studied

  • Skin wound repair

    Animal and cell

    In an animal study, the seven-amino-acid thymosin beta-4 fragment LKKTETQ helped skin wounds repair in aged and diabetic mice about as well as the full-length protein. There is no human trial of the fragment. Source: Wound Repair Regen 2003

  • Cell wound closure

    Animal and cell

    In a cell scratch-wound test, a TB-500 breakdown product (Ac-LKKTE) showed wound-healing activity while TB-500 itself did not. This is cell evidence only. Source: J Chromatogr B 2024

Side effects reported

No human trial in the datasets reports adverse-event rates for TB-500, which has been studied in animals and cells only. Without controlled data, its safety in people is unknown rather than established.

Regulatory status

FDA Philippines
No registered drug product found on the FDA verification portal.
US FDA
No record foundDrugs@FDA returned no approved or tentatively approved application for this substance. Drugs@FDA does not list investigational products. Separately, the FDA lists it on its page of bulk drug substances for compounding that may present significant safety risks (current as of 22 April 2026); that page concerns compounding, not approval.
European Medicines Agency
No record foundNo row for this substance in the EMA medicines report generated 22 September 2026. That report does not cover national authorisations in EU member states.
Next milestone
No sponsor identified in any record read.

Checked 23 September 2026. Primary source

How Philippine registration and prescription rules work, and what an unregistered product is under the law, is covered in the regulation hub, and every compound's status side by side is on the status page. This is general information, not legal advice.

Who should not use TB-500

FAQ

What is the difference between TB-500 and BPC-157?

They are different molecules with different evidence. TB-500 is identified as a fragment of thymosin beta-4, and its evidence is animal and cell studies only. BPC-157 is a synthetic 15-amino-acid peptide, and its strongest evidence in this site's datasets is small human studies. No trial comparing the two appears in those datasets.

Does TB-500 grow hair?

No hair-growth finding for TB-500 is in the evidence datasets this site draws on. Those datasets list what TB-500 has been studied for as wound, corneal and tendon healing in animals, and its evidence level as animal and cell.

What evidence exists for TB-500?

The evidence level for TB-500 is animal and cell. Completed human randomised controlled trials identified: 0 (For the TB-500 fragment. Ten completed human RCTs exist for full-length thymosin beta-4, a different molecule). Studied for: Wound, corneal and tendon healing in animals (fragment and full-length protein); dry eye, corneal healing and skin ulcers in humans (full-length thymosin beta-4 only). Key source: Esposito S et al. Drug Test Anal 2012 (TB-500 identified as Ac-LKKTETQ).

Is TB-500 legal in the Philippines?

FDA Philippines status: No registered drug product found on the FDA verification portal. US FDA: No record found. The regulatory status page sets out the status of every compound in the regulatory dataset.

Where to get TB-500 in the Philippines

Primara Labs, our partner and supplier, lists their current vials on the catalogue. Prices and stock change, so check there for what is available now. View the Primara Labs catalogue

Finished reading and not sure where a 90-day plan would start? Longevity Manila builds one around a single goal, then hands the list to our partner and supplier, Primara Labs.

The supply index covers what to ask a seller before paying, and why quoted prices vary so widely.

Risk · Disclosure · Editorial Status

This page is editorial information for adults researching peptide therapy. It is not medical advice, not a prescription, and not an endorsement of any specific product, supplier, or protocol. Side effects can be serious and individual response varies. Talk to a licensed physician (ideally one with peptide-specific clinical experience) before starting any compound, adjusting a dose, or discontinuing therapy.

In the Philippines, GLP-1 medications are prescription-only under FDA Philippines regulation. Research-grade peptides occupy a regulatory gray area: import for personal research use is generally tolerated, but the Bureau of Customs reserves the right to inspect and detain shipments. Do not import for resale.

Editorial Status
Non-clinical
Affiliation
Not a clinic · Not a pharmacy
Last Updated
September 24, 2026

Updated