Argireline

Argireline is the trade name Lipotec uses for acetyl hexapeptide-3, a synthetic six-amino-acid peptide used in topical skincare products. Browse the full peptide library for related compounds.

Its proposed mechanism is interference with the SNARE protein complex that nerve endings use to release acetylcholine, the signal that makes muscles contract. This page cites no primary study of Argireline, and it is not in the evidence datasets this site draws on, so the page makes no claim about the size of any effect on wrinkles.

Other cosmetic peptides covered on this site include GHK-Cu and SNAP-8.

The supply index covers what to ask a seller, the COA guide explains how certificates of analysis are read, and the peptide legality guide covers Philippine regulation.

SNARE complex (proposed): Argireline is designed to interfere with formation of the SNARE protein complex needed for acetylcholine release at the nerve-muscle junction. This page cites no study that measured it.

Expression lines (proposed): less forceful muscle contraction is the proposed route by which it would soften expression lines. No effect size is claimed here.

Topical delivery: it is applied to the skin rather than injected. How far it penetrates the skin is not established by any source on this page.

Argireline is not yet in the evidence datasets this site draws on, so this page makes no claim about what it does. Anything published about it elsewhere should be read with its evidence level in mind: most peptides in this category have animal or cell data only.

The regulatory dataset this site draws on has no row for Argireline.

The supply index covers what to ask a seller before paying, and why quoted prices vary so widely.

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