Melanotan II

Melanotan II (MT-2) is a synthetic cyclic analogue of alpha-MSH (alpha-melanocyte stimulating hormone) that binds to melanocortin receptors MC1R through MC5R. This multi-receptor binding is why MT-2 has such diverse effects. MC1R activation triggers melanin production (tanning). MC4R activation in the brain suppresses appetite and increases libido. The broad receptor profile produces faster, darker tanning than Melanotan I, plus pronounced effects on sexual function. Browse the full peptide library for related compounds.

MT-2 became widely known in the biohacking community not only for its dramatic tanning effect but also because its MC4 receptor activation produces significant aphrodisiac effects. Men experience spontaneous erections. Both sexes report increased sexual desire. This dual function is either a benefit or side effect depending on your goals.

What should you actually expect? Tanning effect becomes noticeable within 5 to 7 days of use, even with minimal sun exposure. Nausea is common in the first few doses but usually subsides. Libido increase is often reported, sometimes significantly. Appetite suppression is mild to moderate. Moles may darken. Facial flushing after injection is common and lasts 30 to 90 minutes. Be honest with yourself about whether the cosmetic appeal is worth the side effect reality.

Dosing: Loading phase is 0.25mg to 0.5mg subcutaneous daily for 2 to 3 weeks. Maintenance is 0.5mg once or twice per week. Start LOW (0.25mg) because nausea is dose-dependent. Inject before bed to sleep through the nausea. UV exposure helps but is not required for the melanin response. Your body will produce melanin regardless, though sun exposure accelerates the visible darkening.

Safety considerations: MT-2 is one of the more side-effect-heavy peptides. Mole darkening requires monitoring. Any mole that changes shape or color should be seen by a dermatologist. The multi-receptor binding means unpredictable effects across different body systems. Not recommended for people with a history of melanoma or atypical moles. If you have significant mole history, stick to Melanotan I which is more selective.

In Philippines, MT-2 is popular among expats in Makati and Quezon City for the tanning effect in a tropical climate. Available research-grade from regional suppliers. For verified suppliers, see the supply index. Verify purity via the COA guide. For legal context, see the peptide legality guide.

MC1 Activation (Tanning): Activates MC1 receptors on melanocytes, stimulating rapid, dense eumelanin production. The tan develops faster and darker than MT-1 due to greater receptor activation.

MC4 Activation (Sexual Effects): MC4 receptors in the brain hypothalamus regulate sexual function. Activation produces spontaneous erections in men and heightened sexual arousal in both genders. This is also why MT-2 causes appetite suppression.

MC3 Activation: Additional receptor activation in the CNS and peripheral tissues contributes to the broader side effect profile including nausea and energy changes.

• 01Rapid, deep tan — often visible within 1–2 weeks
• 02Dramatic libido enhancement in both men and women
• 03Potential treatment for sexual dysfunction (studied for erectile dysfunction)
• 04Appetite suppression as a secondary effect
• 05Long-lasting tan — maintains with less frequent dosing than MT-1

Always start at the lowest effective dose and titrate up gradually.

See our community-verified supplier list with COA verification and cold-chain shipping to the Philippines.