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Hormones and libido · Compound

Melanotan II

Synthetic cyclic alpha-MSH analogue that binds melanocortin receptors MC1R through MC5R, which are involved in skin pigmentation, appetite and sexual function.

Philippines Peptides editorial deskUpdated Trial data checked 23 September 20264 min read

Melanotan II is not yet in the evidence datasets this site draws on, so this page makes no claim about what it does.

What is Melanotan II

Melanotan II (MT-2) is a synthetic cyclic analogue of alpha-MSH (alpha-melanocyte-stimulating hormone) that binds melanocortin receptors MC1R through MC5R. MC1R on skin melanocytes is involved in melanin production; MC4R in the brain is involved in appetite and sexual function. It binds a wider set of receptors than Melanotan I. Browse the full peptide library for related compounds.

Melanotan II is not in the evidence datasets this site draws on, and this page lists no study sources for it, so the page states no trial findings for it.

How it works

MC1 receptor: MT-2 binds MC1 receptors on melanocytes, the receptor linked to eumelanin production in skin.

MC4 receptor: MT-2 also binds MC4 receptors in the hypothalamus, which are involved in sexual function and appetite. Spontaneous erections and reduced appetite are among the side effects reported for it.

MC3 and MC5 receptors: MT-2 binds these receptors as well, which is the usual explanation given for its broader side-effect profile compared with Melanotan I.

Benefits studied

Melanotan II is not yet in the evidence datasets this site draws on, so this page makes no claim about what it does. Anything published about it elsewhere should be read with its evidence level in mind: most peptides in this category have animal or cell data only.

Side effects reported

No controlled human data on adverse events for Melanotan II is in the datasets this site draws on, so its safety in people is unknown rather than established. Effects commonly described for it are listed below; how often they occur has not been measured in a controlled trial.

  • Nausea
  • Spontaneous erections in men
  • Flushing
  • Reduced appetite
  • Yawning and fatigue
  • Darker or more numerous moles and freckles
  • Dizziness or fainting
  • Abdominal cramping
  • Prolonged erection (priapism)
  • Changes to existing moles

Regulatory status

The regulatory dataset this site draws on has no row for Melanotan II.

Who should not use Melanotan II

Everything above is research framing. If you have got as far as wanting a vial, the catalogue at Primara Labs, our partner and supplier, is the shortest way to see what is held inside the Philippines and at what price. View the Primara Labs catalogue

FAQ

How does Melanotan II differ from Melanotan I?

The difference is receptor selectivity. Melanotan II binds MC1R and also MC3R, MC4R and MC5R; Melanotan I is described as acting mainly at MC1R. The sexual and appetite effects reported for Melanotan II are linked to its MC4R activity. This page cites no study comparing the two compounds in people.

What side effects are reported for Melanotan II?

Side effects listed for Melanotan II include nausea, flushing, reduced appetite, yawning, spontaneous erections in men and darkening of moles and freckles; prolonged erection (priapism) and fainting are listed as rare. These are not frequencies measured in a controlled trial, because this page cites no trial.

What evidence exists for Melanotan II?

Melanotan II is not in the evidence datasets this site draws on, and this page lists no study sources for it, so the page makes no evidence claim.

Where to get Melanotan II in the Philippines

Primara Labs, our partner and supplier, lists their current vials on the catalogue. Prices and stock change, so check there for what is available now. View the Primara Labs catalogue

The supply index covers what to ask a seller before paying, and why quoted prices vary so widely.

View Supply Index

Risk · Disclosure · Editorial Status

This page is editorial information for adults researching peptide therapy. It is not medical advice, not a prescription, and not an endorsement of any specific product, supplier, or protocol. Side effects can be serious and individual response varies. Talk to a licensed physician (ideally one with peptide-specific clinical experience) before starting any compound, adjusting a dose, or discontinuing therapy.

In the Philippines, GLP-1 medications are prescription-only under FDA Philippines regulation. Research-grade peptides occupy a regulatory gray area: import for personal research use is generally tolerated, but the Bureau of Customs reserves the right to inspect and detain shipments. Do not import for resale.

Editorial Status
Non-clinical
Affiliation
Not a clinic · Not a pharmacy
Last Updated
September 24, 2026

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