Kisspeptin is a hormones / reproductive peptide. Typical research dosing is daily or pulsed injection, and the body of supporting research is clinical / well-established.
Kisspeptin (also called metastin) is a naturally occurring neuropeptide encoded by the KISS1 gene. It acts on kisspeptin receptors (KISS1R / GPR54) in the hypothalamus to trigger pulsatile release of Gonadotropin-Releasing Hormone (GnRH). This cascade then stimulates the pituitary to release LH (luteinizing hormone) and FSH (follicle-stimulating hormone), which in turn signal the gonads to produce testosterone (in men) and regulate the menstrual cycle and fertility (in women). Browse the full peptide library for related hormone compounds.
Kisspeptin is considered the master regulator of the reproductive HPG axis. Low kisspeptin activity is associated with hypothalamic amenorrhea in women and hypogonadotropic hypogonadism in men, conditions where the hormonal cascade fails to activate properly. Supplemental kisspeptin can reactivate this cascade.
Unlike exogenous testosterone, kisspeptin works by stimulating the body's own hormone production system. This means it can raise testosterone naturally while preserving testicular function and fertility, a key advantage over anabolic steroids or TRT for users who want hormonal optimization without suppressing natural production.
KISS1R Activation: Kisspeptin binds to KISS1R receptors on GnRH neurons in the hypothalamus (specifically the arcuate nucleus and anteroventral periventricular nucleus). This triggers pulsatile GnRH secretion.
HPG Axis Stimulation: GnRH pulses reach the anterior pituitary, stimulating LH and FSH release. LH then signals Leydig cells in the testes (or ovarian granulosa cells in women) to produce testosterone (or estrogen/progesterone).
Pulsatile vs Continuous: Kisspeptin is most effective when administered in a pulsatile fashion mimicking natural rhythm, as continuous high-dose administration can paradoxically desensitize receptors and reduce the hormonal response over time.
Kisspeptin is not on the FDA Philippines registered drug list. The licensed HPG-axis tools here are clomiphene (Clomid), enclomiphene (where compounded), hCG injections, and TRT through Manila endocrinology: Makati Medical Center, St. Luke's BGC, and The Medical City all run men's health and fertility clinics that prescribe these. Kisspeptin sits outside that as a research-grade peptide, used by Manila users who specifically want HPG-axis stimulation that preserves natural production rather than the suppression that comes with exogenous testosterone.
The bloodwork before starting matters more here than for most peptides. Hi-Precision and Makati Med run the full hormone panel (total testosterone, free testosterone, SHBG, LH, FSH, estradiol, and prolactin) for around ₱5,500–7,500. AM draw, fasted, before 10am. Manila men's testosterone numbers tend to skew lower than Western averages in part due to lifestyle factors (sleep debt from traffic, body composition, stress cortisol), so the baseline is often genuinely worth optimizing. Repeat panel at week 4–6 to confirm response.
The pulsatile vs continuous dosing decision is where most users get this wrong. Kisspeptin-54 has a short half-life and the natural HPG rhythm is pulsatile: twice-daily SC injections AM and PM (fasted) at 3–10mcg/kg are what the Salam Hospital, Imperial College, and Anastasia Dimitriadis clinical work used. Continuous high-dose protocols (which some research-peptide forums recommend) actually desensitize the receptors over time and produce worse outcomes than properly timed pulses.
Makati Medical Center · Makati
Endocrinology, men's health clinic, full hormone panel and fertility workup.
St. Luke's BGC · BGC
Reproductive endocrinology, fertility clinic, full HPG bloodwork.
The Medical City · Pasig
Men's health, andrology, TRT and fertility workup.
Asian Hospital · Alabang
Endocrinology and reproductive medicine; outpatient labs.
Mercury Drug · Nationwide
Carries clomiphene (Clomid) and hCG (Rx). No kisspeptin.
Watsons · Nationwide
Carries some hormonal medications by prescription. No kisspeptin.
| Item | PHP | USD | Source |
|---|---|---|---|
| Kisspeptin-10 5mg vial (research-grade) | ₱2,800–3,800 | $50–68 | International peptide suppliers, shipped to Manila |
| Kisspeptin-54 5mg vial (research-grade) | ₱4,500–6,000 | $80–107 | International peptide suppliers |
| BAC water 30mL | ₱350–500 | $6–9 | Manila compounding pharmacies |
| Insulin syringes 31g (box of 100) | ₱650–900 | $12–16 | Mercury Drug, Watsons |
| Full HPG hormone panel (T, fT, SHBG, LH, FSH, E2, prolactin) | ₱5,500–7,500 | $98–134 | Hi-Precision, Makati Med outpatient |
| Repeat hormone panel at week 4–6 | ₱5,500–7,500 | $98–134 | Hi-Precision, Makati Med outpatient |
Customs & import reality
Kisspeptin ships into Manila as research peptide; single-vial parcels through Singapore or Hong Kong forwarders typically clear BOC without intervention. Cold-chain through Manila summer is the operational risk: the kisspeptin-54 longer chain is more sensitive to thermal degradation than kisspeptin-10, and a vial that sat in a customs warehouse at 35°C for a few days is functionally inert regardless of paperwork.
| Phase | Dose | Frequency | Duration |
|---|---|---|---|
| Standard pulse | 3–10mcg/kg | Twice daily (AM + PM, fasted) | 4–8 weeks |
| PCT support | 10–25mcg | Daily | 6–8 weeks post-cycle |
Always start at the lowest effective dose and titrate up gradually.
Turning a dose in milligrams into units on a syringe is arithmetic, not judgement. The reconstitution calculator does it for any vial size, and the rest of the calculator set covers cost per milligram and route comparison.
Vials at Primara Labs, our partner and supplier, ship from stock already inside the Philippines, so an order has no customs leg. Their catalogue is the shortest route to what is listed locally and at what price, and anything outside it goes through the same WhatsApp thread. View the Primara Labs catalogue
LH and FSH begin to rise. Some users notice increased libido and morning erections (for men). Testosterone levels begin to elevate. Effects are gradual.
Testosterone levels typically approaching their new elevated baseline. Improved energy, mood, and sexual function commonly reported.
Sustained elevated testosterone. Best to blood test at this point to confirm response. Can continue use or cycle off and allow natural axis to maintain.
Everything above is research framing. If you have got as far as wanting a vial, the catalogue at Primara Labs, our partner and supplier, is the shortest way to see what is held inside the Philippines and at what price. View the Primara Labs catalogue
Our partner and supplier
Primara Labs, our partner and supplier, ships from inventory already inside the Philippines, so there is no customs leg: vials are batch-numbered, Metro Manila orders dispatch same day, the rest of the country lands in one to three business days, and every order gets 10% off. The current list sits on one page, and anything you cannot see on it goes through the same WhatsApp thread.
View the Primara Labs catalogueThe supply index covers what to ask a seller before paying, and why quoted prices vary so widely.
Citations supporting the clinical claims on this page. Each entry links to the primary record.
Kisspeptin-54 in human males, Dhillo 2005
TrialDhillo WS, Chaudhri OB, Patterson M, et al. "Kisspeptin-54 stimulates the hypothalamic-pituitary-gonadal axis in human males." J Clin Endocrinol Metab 2005;90(12):6609–6615.
DOI: 10.1210/jc.2005-1468Kisspeptin-54 LH pulsatility in women, Jayasena 2013
TrialJayasena CN, Comninos AN, Veldhuis JD, et al. "A single injection of kisspeptin-54 temporarily increases luteinizing hormone pulsatility in healthy women." Clin Endocrinol 2013;79(4):558–563.
DOI: 10.1111/cen.12179Kisspeptin physiology review, Pinilla 2012
ReviewPinilla L, Aguilar E, Dieguez C, et al. "Kisspeptins and reproduction: physiological roles and regulatory mechanisms." Physiol Rev 2012;92(3):1235–1316.
DOI: 10.1152/physrev.00037.2010Kisspeptin and emotional brain processing, Comninos 2017
TrialComninos AN, Wall MB, Demetriou L, et al. "Kisspeptin modulates sexual and emotional brain processing in humans." J Clin Invest 2017;127(2):709–719.
DOI: 10.1172/JCI89519FDA Philippines drug registry: kisspeptin not listed
ReferenceFDA Philippines Registered Drug Products Database. Verified 2026-05-07: kisspeptin has no Philippine drug registration; clomiphene and hCG registered separately for distinct fertility indications.
SourceRisk · Disclosure · Editorial Status
This page is editorial information for adults researching peptide therapy. It is not medical advice, not a prescription, and not an endorsement of any specific product, supplier, or protocol. Side effects can be serious and individual response varies. Talk to a licensed physician (ideally one with peptide-specific clinical experience) before starting any compound, adjusting a dose, or discontinuing therapy.
In the Philippines, GLP-1 medications are prescription-only under FDA Philippines regulation. Research-grade peptides occupy a regulatory gray area: import for personal research use is generally tolerated, but the Bureau of Customs reserves the right to inspect and detain shipments. Do not import for resale.
Editorial Status
Independent · Non-clinical
Affiliation
Not a clinic · Not a pharmacy
Last Updated
August 27, 2026
