CJC-1295 (with DAC)
Category
Growth Hormone
Frequency
1–2x weekly
Research
Phase 2 Clinical Trials
What is CJC-1295 (with DAC)
CJC-1295 with DAC (Drug Affinity Complex) is a modified form of Growth Hormone Releasing Hormone (GHRH) that includes a Drug Affinity Complex — a chemical modification that allows it to bind to albumin in the blood, dramatically extending its half-life from minutes to 6–8 days. Browse the full peptide library for related GH compounds.
This long half-life enables once or twice weekly dosing, creating what is known as a "GH bleed" — a sustained elevation in growth hormone levels rather than sharp pulsatile spikes. This is fundamentally different from CJC-1295 without DAC, which produces short, natural-pattern GH pulses.
The sustained GH elevation from CJC-1295 with DAC is preferred by users seeking body composition changes (more muscle, less fat) over the long-term, as it maintains growth factor levels more consistently. For clean, pulsatile GH release, consider stacking with ipamorelin. For clinically validated visceral fat reduction, tesamorelin has FDA approval for that specific indication. However, some argue that constant GH elevation is less physiological than pulsatile release.
How it works
GHRH Mimicry: CJC-1295 (with DAC) binds to the GHRH receptor in the pituitary gland, stimulating the release of growth hormone.
Albumin Binding: The DAC modification causes the peptide to bind to albumin (the most abundant blood plasma protein), protecting it from enzymatic degradation and extending its half-life to 6–8 days.
IGF-1 Elevation: Elevated GH stimulates the liver to produce IGF-1 (Insulin-like Growth Factor 1), which is responsible for many of GH's anabolic and regenerative effects in muscle and connective tissue.
Reported benefits
- 01Once or twice weekly dosing convenience
- 02Sustained GH and IGF-1 elevation
- 03Improved lean muscle mass and body composition
- 04Enhanced fat oxidation, especially visceral fat
- 05Improved recovery and connective tissue health
- 06Better sleep architecture
- 07Anti-aging and skin quality improvements
Dosing protocol
| Phase | Dose | Frequency | Duration |
|---|---|---|---|
| Standard | 1–2mg | Once per week | 8–12 weeks |
| Stacked (with Ipa) | 1mg CJC + 300mcg Ipa | 2–3x per week | 12 weeks |
Always start at the lowest effective dose and titrate up gradually.
Side effects
Common
- Water retention (can be significant)
- Tingling in hands and feet
- Fatigue in first 1–2 weeks
- Mild headaches
- Increased hunger
Rare
- ·Hypoglycemia (if injected near meal)
- ·Elevated cortisol in sensitive individuals
- ·Carpal tunnel syndrome with long-term high dose use
Who should not use CJC-1295 (with DAC)
What to expect
Week 1–2
Water retention noticeable. Sleep may improve. Mild fatigue as GH levels rise.
Week 3–6
Body composition begins shifting. Recovery faster. Skin quality improving.
Month 2–3
Clear anabolic effects. Lean mass increasing. Fat (especially visceral) decreasing.
Month 3+
Full benefits established. Most cycle 12 weeks on, 4–8 weeks off.
FAQ
CJC-1295 with DAC or without DAC — which should I choose?
With DAC gives a GH bleed (sustained elevation, dosed weekly). Without DAC gives pulsatile release (more natural, dosed daily). With DAC is more convenient but the constant elevation may cause more water retention. For body composition goals, with DAC is often preferred. For sleep and recovery, without DAC + Ipamorelin before bed is often better.
Should I combine CJC-1295 (with DAC) with Ipamorelin?
Yes, but note that with DAC the Ipamorelin is less critical than with the no-DAC version because CJC-DAC already provides sustained stimulation. Many users do add Ipamorelin doses 2–3x weekly for additional GH pulses. Source from the community-verified supplier list.
Where to get CJC-1295 (with DAC) in the Philippines
See our community-verified supplier list with COA verification and cold-chain shipping to the Philippines.
Risk · Disclosure · Editorial Status
This page is editorial information for adults researching peptide therapy. It is not medical advice, not a prescription, and not an endorsement of any specific product, supplier, or protocol. Side effects can be serious and individual response varies. Talk to a licensed physician — ideally one with peptide-specific clinical experience — before starting any compound, adjusting a dose, or discontinuing therapy.
In the Philippines, GLP-1 medications are prescription-only under FDA Philippines regulation. Research-grade peptides occupy a regulatory gray area: import for personal research use is generally tolerated, but the Bureau of Customs reserves the right to inspect and detain shipments. Do not import for resale.
Editorial Status
Independent · Non-clinical
Affiliation
Not a clinic · Not a pharmacy
Last Updated
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