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Cognitive and sleep · Compound
DSIP
Delta sleep-inducing peptide: a nine-amino-acid peptide first isolated from rabbit blood, studied in small human studies of sleep, insomnia and pituitary hormones.
Philippines Peptides editorial deskUpdated Trial data checked 23 September 20268 min read5 sources
The strongest evidence found for DSIP comes from small human studies, and every finding below carries its evidence level.
What is DSIP
DSIP (delta sleep-inducing peptide) is a nine-amino-acid peptide first isolated from rabbit blood in 1977, when Schoenenberger and Monnier characterised it in rabbits as a peptide inducing delta (slow-wave) EEG activity. Browse the full peptide library for related sleep and mood compounds.
In people, DSIP has been studied for chronic insomnia and sleep, withdrawal states (in uncontrolled studies), pituitary hormones and as an adjunct to anaesthesia. The human studies are small, run between 1981 and 2009 with 6 to 24 participants each. The two with stated random allocation measured anaesthesia depth and ACTH, not sleep, and several placebo-controlled insomnia studies gave mixed results.
How it works
Mechanism: unknown. No gene, precursor protein or receptor for DSIP has been identified, and a 2006 review by Kovalzon and Strekalova describes its link to sleep as poorly characterised.
Sleep: in a 1992 placebo-controlled study of 16 people with chronic insomnia, sleep efficiency was higher and sleep onset shorter than on placebo, but the authors judged the effects weak and not of major therapeutic benefit.
Stress hormones: in small human studies the effect on ACTH was inconsistent. A randomised crossover study of 11 healthy men found lower blood ACTH-like activity for at least 3 hours with no change in cortisol, while a 1995 placebo-controlled study found no effect on ACTH or cortisol.
DSIP in the Philippines
A search of the FDA Philippines registered drug products database on 7 May 2026, listed in the sources below, found no Philippine drug registration for DSIP. A repeat search on 23 September 2026 could not be completed because the verification portal timed out, so the regulatory section on this page shows its current Philippine status as not established.
Benefits studied
Sleep in chronic insomnia (weak, mixed)
Small human studies
A 1992 placebo-controlled study of 16 people with chronic insomnia found higher sleep efficiency and shorter sleep onset on DSIP, but its authors judged the effects weak and of no major therapeutic benefit. Source: Neuropsychobiology 1992
Daytime sleep in healthy volunteers
Small human studies
A 1981 placebo-controlled crossover study of 6 healthy volunteers found total sleep time over the next 130 minutes rose a median 59% against placebo. Source: Europe PMC 6895513
ACTH levels (inconsistent)
Small human studies
A randomised crossover study of 11 healthy men found DSIP lowered blood ACTH-like activity for at least 3 hours with cortisol unchanged; a 1995 placebo-controlled study found no effect on either. Source: Psychoneuroendocrinology 1989
Side effects reported
No human trial in the datasets reports adverse-event rates for DSIP, whose human evidence is limited to small human studies (2 completed randomised trials identified). Without controlled data, its safety in people is unknown rather than established.
DSIP in the Philippines
DSIP, delta sleep-inducing peptide, is sold in the Philippines as a research compound, not as a sleep medicine. This site has not published an FDA Philippines registration result for DSIP: the 23 September 2026 portal search behind the regulation hub did not include the name, and the store's own search the same day timed out. No FDA Philippines advisory in this site's regulation dataset, checked 23 September 2026, names DSIP.
Primara Labs, our partner and supplier, lists DSIP as "Lyophilized powder, 10 mg / vial", and the sourcing card on this page links it. The legal research behind this site found no Philippine FDA, DOH, BOC or DDB document that addresses products labelled research use only. In the United States, the FDA lists DSIP on its page of bulk drug substances for compounding that may present significant safety risks (current as of 22 April 2026); that page concerns compounding, not approval.
For research context, the name promises more than the studies show. DSIP was first isolated from rabbit blood in 1977, no receptor for it has been identified, and a 2006 review describes its link to sleep as poorly characterised. The human studies the evidence dataset found are small ones from the early 1980s to 2009. The 2 with stated random allocation measured anaesthesia depth and ACTH rather than sleep, and the placebo-controlled insomnia studies gave mixed results. The dataset rates the whole body of work as small human studies. Prescribing for insomnia belongs with a licensed Philippine physician. The status page lists DSIP with the other research compounds.
Regulatory status
FDA Philippines
Not publishedCould not be established: the FDA Philippines verification portal search timed out on 23 September 2026, retried the same day in a browser with the same result.
US FDA
No record foundDrugs@FDA returned no approved or tentatively approved application for this substance. Drugs@FDA does not list investigational products. Separately, the FDA lists it on its page of bulk drug substances for compounding that may present significant safety risks (current as of 22 April 2026); that page concerns compounding, not approval.
European Medicines Agency
No record foundNo row for this substance in the EMA medicines report generated 22 September 2026. That report does not cover national authorisations in EU member states.
How Philippine registration and prescription rules work, and what an unregistered product is under the law, is covered in the regulation hub, and every compound's status side by side is on the status page. This is general information, not legal advice.
Who should not use DSIP
Everything above is research framing. For the material itself, our partner and supplier lists DSIP 10mg at Primara Labs for ₱2,210 (₱1,990 with 10% off), from stock inside the Philippines.
FAQ
Is DSIP an approved sleep medicine anywhere?
Not in the United States or the European Union. US FDA: No record found. EMA: No record found. This site has not published an FDA Philippines registration result for DSIP: the 23 September 2026 portal search behind the regulation hub did not include the name, and the store's own search the same day timed out.
Has FDA Philippines issued an advisory on DSIP?
No FDA Philippines advisory in this site's regulation dataset, checked 23 September 2026, names DSIP.
Can DSIP be brought into the Philippines from abroad?
This site has no Philippine registration result on record for DSIP. DOH-FDA-BOC Joint Circular No. 1, dated 22 June 2015, lets travellers bring listed FDA-regulated products into the Philippines without prior FDA clearance if the products are for personal use and within set limits. For prescription drugs, Joint Circular No. 1 sets the allowed quantity as the amount stated on a prescription that carries the physician's PRC licence number or a foreign equivalent. Joint Circular No. 1 does not say whether its prescription-drug allowance covers drugs without a Philippine CPR. No FDA circular that answers this was found. The Bureau of Customs lists pharmaceutical products as regulated imports that require a valid Certificate of Product Registration and/or an FDA License to Operate as importer. This is general information, not legal advice.
What evidence exists for DSIP?
The evidence for DSIP is rated small human studies. Human studies ran from 1981 to 2009 and enrolled 6 to 24 people each. Two completed human randomised trials were identified in Europe PMC, and neither measured a sleep outcome: they measured anaesthesia depth and ACTH. Several placebo-controlled insomnia studies gave mixed results.
Has DSIP been studied in insomnia?
Yes, in small studies. In a 1992 placebo-controlled study of 16 people with chronic insomnia, sleep efficiency was higher and sleep onset shorter than on placebo, but the authors judged the effects weak and not of major therapeutic benefit. In a 1981 placebo-controlled crossover study of 6 healthy volunteers, total sleep time in the following 130 minutes rose by a median 59% compared with placebo.
How does DSIP work?
Its mechanism is unknown. No gene, precursor protein or receptor for DSIP has been identified, and a 2006 review describes its link to sleep as poorly characterised.
Is DSIP registered with FDA Philippines?
Its FDA Philippines status could not be established: the FDA Philippines verification portal search timed out on 23 September 2026, and a same-day retry in a browser gave the same result. In the US, Drugs@FDA returned no approved or tentatively approved application for it, and the European Medicines Agency medicines report has no row for it. See regulatory status by compound.
Where to get DSIP in the Philippines
Finished reading and not sure where a 90-day plan would start? Longevity Manila builds one around a single goal, then hands the list to our partner and supplier, Primara Labs.
The supply index covers what to ask a seller before paying, and why quoted prices vary so widely.
FDA Philippines drug registry: DSIP not listedReference
FDA Philippines Registered Drug Products Database. Verified 2026-05-07: DSIP has no Philippine drug registration; available only as research-grade peptide.
This page is editorial information for adults researching peptide therapy. It is not medical advice, not a prescription, and not an endorsement of any specific product, supplier, or protocol. Side effects can be serious and individual response varies. Talk to a licensed physician (ideally one with peptide-specific clinical experience) before starting any compound, adjusting a dose, or discontinuing therapy.
In the Philippines, GLP-1 medications are prescription-only under FDA Philippines regulation. Research-grade peptides occupy a regulatory gray area: import for personal research use is generally tolerated, but the Bureau of Customs reserves the right to inspect and detain shipments. Do not import for resale.
