Last revision · Mar 2026
Compounds covered
03
Avg loss range
15 – 29%
Dosing
Once weekly
Cold-chain
Required
Sourcing note: most readers of this site buy retatrutide from Primara Labs, our partner and supplier. Stock sits inside the Philippines, vials are batch-numbered and shipped cold-chain, and Metro Manila orders verified before noon go out the same day. Retatrutide price Philippines
GLP-1 (glucagon-like peptide-1) is a hormone your body naturally produces after eating. It signals satiety, tells your pancreas to release insulin, and slows digestion. GLP-1 agonist peptides mimic this hormone at higher levels, producing strong, durable effects on appetite and weight.
The three main GLP-1 peptides available today are Semaglutide (Ozempic / Wegovy), Tirzepatide (Mounjaro / Zepbound), and Retatrutide, a triple agonist still in Phase 3.
| Peptide | Hospital / pharmacy | Research-grade |
|---|---|---|
| Semaglutide (Ozempic) | Yes, major hospitals | Widely available |
| Tirzepatide (Mounjaro) | Limited, call ahead | Widely available |
| Retatrutide | Not available anywhere | Research-grade sellers only |
| Factor | Semaglutide | Tirzepatide | Retatrutide |
|---|---|---|---|
| Receptors | 1 (GLP-1) | 2 (GLP-1+GIP) | 3 (GLP-1+GIP+Glu) |
| Avg weight loss | 15% | 22.5% | 24 – 29% |
| FDA approved | Yes (2017/2021) | Yes (2022/2023) | Phase 3 |
| Dosing | Weekly | Weekly | Weekly |
| PH monthly cost | USD 90 – 200 | USD 130 – 400 | ~USD 250 |
Appetite suppression. GLP-1 acts on receptors in the brain that control hunger. Users consistently report dramatically reduced hunger and disappearance of constant food noise.
Slower gastric emptying. Food stays in your stomach longer, creating extended fullness. Also why eating too fast causes nausea: your stomach can't process it as quickly.
Improved insulin response. GLP-1s enhance insulin secretion in response to food, improving blood sugar control. This is why they were originally developed for type 2 diabetes.
Glucagon activation (retatrutide only). Retatrutide's third receptor directly increases metabolic rate. Your body burns more calories at rest, including stored fat. This explains the extra ~6% weight loss vs tirzepatide.
| Timeframe | What happens |
|---|---|
| Week 1 – 2 | Appetite begins decreasing. Side effects (nausea) peak. No significant weight change yet. |
| Week 3 – 4 | Nausea subsides. First noticeable weight loss (1 – 3kg). Eating less feels natural. |
| Month 2 – 3 | Steady weight loss (1 – 2kg/week). Energy improves. Clothes fit differently. |
| Month 4 – 6 | Approaching goal weight. Rate of loss slows. Body composition improving. |
| Month 6+ | Maintenance phase. Some users reduce dose. Lifestyle changes solidify. |
Hospital / international clinic. Brand-name Ozempic and Mounjaro available at Makati Medical Center, Manila Doctors Hospital, and select international pharmacies. Pharmaceutical-grade with doctor supervision; expensive and limited to approved compounds.
Research-grade sourcing. Access to retatrutide and the lower-cost tirzepatide / semaglutide route. Batch-numbered, cold-chain shipped, often with physician review. See /supply for the current verified list.
Climate. Heat degrades peptides quickly. Ensure cold-chain to your door, immediate refrigeration on receipt (2 – 8°C), never leave vials at room temperature.
Supplies. Insulin syringes are available at Watsons and Mercury Drug nationwide without prescription.
Alcohol. GLP-1s significantly reduce alcohol tolerance. One drink hits like three. Start slow if drinking.
Local support. Join r/PeptidesPhilippines for region-specific questions, supplier feedback, and local experiences.
Our partner and supplier
Primara Labs, our partner and supplier, holds stock inside the Philippines. Vials are batch-numbered and ship cold-chain, Metro Manila orders verified before noon dispatch the same day, provincial couriers run 1 to 3 days, and every order gets 10% off.
Buy retatrutide in the Philippines