NAD+
Category
Longevity & Energy
Frequency
Daily (oral) or weekly (IV/injectable)
Research
Extensive Preclinical + Human Trials
What is NAD+
NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in every living cell. It is essential for over 500 enzymatic reactions including the production of ATP (cellular energy), DNA repair, and the activation of sirtuins — a family of proteins that regulate aging, metabolism, and stress resistance. Browse the full peptide library for related longevity compounds.
NAD+ levels decline by approximately 50% between ages 40 and 60, which correlates directly with the hallmarks of aging: reduced energy, slower recovery, impaired DNA repair, and metabolic dysfunction. For mitochondrial optimization, consider combining with MOTS-c. Replenishing NAD+ through supplementation has become one of the most scientifically credible longevity interventions.
Injectable or IV NAD+ delivers the coenzyme directly into the bloodstream, bypassing digestive breakdown that limits oral supplementation (NMN and NR are oral precursors). For telomere extension, combine with Epitalon. Injectable NAD+ is used in addiction treatment, neurological recovery, and as an anti-aging protocol.
How it works
Sirtuin Activation: NAD+ is the essential cofactor for sirtuin proteins (SIRT1–7), which regulate gene expression, DNA repair, inflammation, and metabolic function. Higher NAD+ levels = more active sirtuins = better cellular maintenance.
PARP Activation: NAD+ fuels PARP enzymes (Poly ADP-Ribose Polymerases) which are critical for DNA repair. DNA damage accumulates with age; robust PARP activity keeps the genome stable.
ATP Production: NAD+ is the electron carrier in the mitochondrial electron transport chain — the final step in cellular energy production. More NAD+ = more efficient ATP production = more energy.
CD38 Regulation: CD38 (an NADase enzyme) increases with aging and consumes NAD+. Strategies that inhibit CD38 while supplementing NAD+ amplify results.
Reported benefits
- 01Increased cellular energy and reduced fatigue
- 02Enhanced DNA repair capacity
- 03Sirtuin activation — downstream anti-aging effects
- 04Improved cognitive function and mental clarity
- 05Metabolic improvements (insulin sensitivity, mitochondrial function)
- 06Faster recovery from exercise and injury
- 07Neuroprotection and addiction recovery support
- 08Potential lifespan extension (animal models)
Dosing protocol
| Phase | Dose | Frequency | Duration |
|---|---|---|---|
| Oral (NMN/NR) | 500–1000mg | Once daily with breakfast | Ongoing |
| Injectable NAD+ | 100–500mg | Once daily SC or IM | 5–10 day course |
| IV Drip | 250–1000mg | Once weekly | Ongoing |
Always start at the lowest effective dose and titrate up gradually.
Side effects
Common
- Flushing (particularly with rapid IV infusion)
- Nausea during IV administration (slow the drip)
- Muscle cramping or tight chest during IV (from rapid rate)
- Headache
- Fatigue in first 1–2 days (detox response)
Rare
- ·Anxiety or restlessness at high IV doses
- ·Hypotension with rapid IV infusion
Who should not use NAD+
What to expect
Day 1–3
IV or injectable NAD+ often produces immediate energy and mood effects. Flushing and nausea possible during infusion.
Week 1–2
Sustained energy improvement. Cognitive clarity often notable. Sleep quality may improve.
Month 1–3
Metabolic improvements. Better exercise recovery. Oral users see more gradual benefits over this timeframe.
Month 3+
Long-term benefits accumulate. Many users do quarterly IV courses with daily oral NMN for maintenance.
FAQ
Is injectable NAD+ better than NMN or NR?
Injectable NAD+ directly raises blood NAD+ levels immediately. NMN and NR are oral precursors that must be converted to NAD+ in cells. Injectable is faster and produces stronger acute effects. NMN/NR oral is more convenient and suitable for maintenance.
Can I stack NAD+ with other longevity peptides?
Yes. NAD+ + Epitalon + MOTS-c is a popular longevity stack. They target complementary pathways: NAD+ for energy and sirtuin activation, Epitalon for telomere maintenance, MOTS-c for mitochondrial optimization. Source from the community-verified supplier list. For IV drip clinics and home injection protocols in Makati and Quezon City, see the NAD+ therapy guide for Philippines.
Where to get NAD+ in the Philippines
See our community-verified supplier list with COA verification and cold-chain shipping to the Philippines.
Risk · Disclosure · Editorial Status
This page is editorial information for adults researching peptide therapy. It is not medical advice, not a prescription, and not an endorsement of any specific product, supplier, or protocol. Side effects can be serious and individual response varies. Talk to a licensed physician — ideally one with peptide-specific clinical experience — before starting any compound, adjusting a dose, or discontinuing therapy.
In the Philippines, GLP-1 medications are prescription-only under FDA Philippines regulation. Research-grade peptides occupy a regulatory gray area: import for personal research use is generally tolerated, but the Bureau of Customs reserves the right to inspect and detain shipments. Do not import for resale.
Editorial Status
Independent · Non-clinical
Affiliation
Not a clinic · Not a pharmacy
Last Updated
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