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Hormones and libido · Compound

Melanotan I

Synthetic alpha-MSH analogue, also known as afamelanotide, that targets the melanocortin-1 receptor involved in skin pigmentation.

Philippines Peptides editorial deskUpdated Trial data checked 23 September 20264 min read

Melanotan I is not yet in the evidence datasets this site draws on, so this page makes no claim about what it does.

What is Melanotan I

Melanotan I (MT-1), also known as afamelanotide, is a synthetic analogue of the hormone alpha-melanocyte-stimulating hormone (alpha-MSH). It is designed to act mainly at the melanocortin-1 receptor (MC1R) on melanocytes, the skin cells that make the pigment melanin. Browse the full peptide library for related compounds.

Melanotan II binds a wider set of melanocortin receptors (MC1R and MC3R to MC5R). Melanotan I is described as more selective for MC1R. This page cites no study comparing the two compounds in people.

Melanotan I is not in the evidence datasets this site draws on, and this page lists no study sources for it, so the page states no trial findings for it.

How it works

MC1 receptor: MT-1 binds melanocortin-1 receptors on melanocytes in the basal layer of the epidermis. Activation of this receptor raises the activity of tyrosinase, the enzyme that starts melanin production.

Melanin synthesis: tyrosinase converts tyrosine to DOPA and on to eumelanin, the dark brown to black pigment in skin. This page cites no study measuring how much MT-1 changes skin pigmentation or UV protection.

Benefits studied

Melanotan I is not yet in the evidence datasets this site draws on, so this page makes no claim about what it does. Anything published about it elsewhere should be read with its evidence level in mind: most peptides in this category have animal or cell data only.

Side effects reported

No controlled human data on adverse events for Melanotan I is in the datasets this site draws on, so its safety in people is unknown rather than established. Effects commonly described for it are listed below; how often they occur has not been measured in a controlled trial.

  • Flushing
  • Nausea
  • Fatigue or yawning
  • Darkening of existing moles
  • Mild headache
  • New moles or changes to existing moles
  • Dizziness
  • Spontaneous erections

Regulatory status

The regulatory dataset this site draws on has no row for Melanotan I.

Who should not use Melanotan I

FAQ

How does Melanotan I differ from Melanotan II?

Melanotan I is described as acting mainly at the MC1 receptor. Melanotan II binds MC1R and also MC3R, MC4R and MC5R, and the effects reported for it include sexual arousal and appetite changes, which are linked to those additional receptors. Neither compound is in the evidence datasets this site draws on, and this page cites no head-to-head study.

Are new moles a concern with Melanotan I?

New moles and darkening of existing moles are among the side effects reported for Melanotan I, which is why a history of melanoma or atypical moles is listed as a contraindication on this page. This page cites no study measuring the size of that risk.

What evidence exists for Melanotan I?

Melanotan I is not in the evidence datasets this site draws on, and this page lists no study sources for it, so the page makes no evidence claim. The side effects listed on this page are not frequencies measured in a controlled trial.

Where to get Melanotan I in the Philippines

Primara Labs, our partner and supplier, lists their current vials on the catalogue. Prices and stock change, so check there for what is available now. View the Primara Labs catalogue

The supply index covers what to ask a seller before paying, and why quoted prices vary so widely.

View Supply Index

Risk · Disclosure · Editorial Status

This page is editorial information for adults researching peptide therapy. It is not medical advice, not a prescription, and not an endorsement of any specific product, supplier, or protocol. Side effects can be serious and individual response varies. Talk to a licensed physician (ideally one with peptide-specific clinical experience) before starting any compound, adjusting a dose, or discontinuing therapy.

In the Philippines, GLP-1 medications are prescription-only under FDA Philippines regulation. Research-grade peptides occupy a regulatory gray area: import for personal research use is generally tolerated, but the Bureau of Customs reserves the right to inspect and detain shipments. Do not import for resale.

Editorial Status
Non-clinical
Affiliation
Not a clinic · Not a pharmacy
Last Updated
September 24, 2026

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