In TRIUMPH-1, a 80-week phase 3 trial of 2,339 adults with obesity or overweight without diabetes, body weight fell 28.3% on the 12 mg retatrutide arm, against 2.2% on placebo. TRIUMPH-1 adverse events: Nausea: 28.6%, 38.4% and 42.4% on the 4, 9 and 12 mg arms, against 14.8% on placebo; Discontinuation for adverse events: 4.1%, 6.9% and 11.3% on the 4, 9 and 12 mg arms, against 4.9% on placebo.
In SURMOUNT-1, a 72-week phase 3 trial of 2,539 adults with obesity or overweight without diabetes, body weight fell 20.9% on the 15 mg tirzepatide arm, against 3.1% on placebo. SURMOUNT-1 adverse events: Discontinuation for adverse events: 4.3%, 7.1% and 6.2% on the 5, 10 and 15 mg arms, against 2.6% on placebo.
In STEP 1, a 68-week phase 3 trial of 1,961 adults with obesity or overweight without diabetes, body weight fell 14.9% on the 2.4 mg semaglutide arm, against 2.4% on placebo.
Two caveats before anyone treats this table as a leaderboard. First, these are separate trials with different durations and populations, not one head-to-head. The head-to-head that does exist compared tirzepatide with semaglutide: In SURMOUNT-5, a 72-week phase 3b trial of 751 adults with obesity and no type 2 diabetes that compared the two directly, body weight fell 20.2% on tirzepatide against 13.7% on semaglutide, each at the maximum tolerated dose. Second, each figure is the highest-dose arm of its trial, and a trial average is not a personal forecast.
Retatrutide also has an earlier phase 2 result: in a 48-week phase 2 trial of 338 adults with obesity or overweight, body weight fell 24.2% on the 12 mg arm, against 2.1% on placebo. The phase 3 figure above is the more mature one.