CJC-1295 / Ipamorelin Protocol
Why Stack These Two
CJC-1295 (GHRH)
Baseline GH elevation
IPAMORELIN (GHRP)
Pulsatile GH spike
COMBINED EFFECT
~3–5× monotherapy
RECEPTOR PATHS
Different + synergistic
CJC-1295is a Growth Hormone Releasing Hormone (GHRH) analogue that elevates baseline GH secretion by amplifying the pituitary's GH output over several hours, the "foundation" of elevated GH throughout the day.
Ipamorelinis a Growth Hormone Releasing Peptide (GHRP) that triggers a clean, strong GH pulse from the pituitary without significantly raising cortisol or prolactin, the "spike" on top of CJC's baseline. GHRH analogues and GHRPs work on different receptors via different mechanisms, so combining them produces a GH pulse roughly 3–5× greater than either alone.
Dosing Protocol
| Time | Peptide | Dose | Notes |
|---|---|---|---|
| Before bed (fasted 2+ hrs) | CJC-1295 no-DAC | 100mcg | Same syringe as Ipamorelin |
| Before bed (fasted 2+ hrs) | Ipamorelin | 200mcg | Mix with CJC in same syringe |
| Optional: Pre-workout (fasted) | CJC-1295 no-DAC | 100mcg | Second pulse for advanced users |
| Optional: Pre-workout (fasted) | Ipamorelin | 200mcg | Second pulse for advanced users |
NOTE: Always inject fasted (min 2 hrs after food, 30–60 min before food). Insulin blunts GH release.
Cycle Structure
- C-01
Beginner: 6 weeks on / 2 off
Single bedtime injection only. 1× CJC + 1× Ipamorelin per day. Assess sleep quality, body composition.
- C-02
Intermediate: 8 weeks on / 4 off
Bedtime injection required, optional second pre-workout pulse. Expect more pronounced body composition changes.
- C-03
Advanced: 3 months on / 1 off
Two daily injections. Some users run longer cycles with lab monitoring of IGF-1 levels.
- C-04
DAC variant
CJC-1295 with DAC: inject once or twice weekly (half-life ~8 days). Ipamorelin still daily at bedtime.
What to Expect
| Period | Expected Effect |
|---|---|
| Week 1–2 | Improved sleep quality, deeper cycles, vivid dreams. Energy begins to improve. |
| Week 3–4 | Slight muscle fullness, reduction in soft fat (especially midsection). |
| Month 2 | More significant body composition. Muscle definition improves, recovery accelerates. |
| Month 3+ | Skin quality, reduced joint soreness, IGF-1 elevation if measured. |
Key Tips
- T-01Inject fasted: never within 2 hrs of eating. Insulin suppresses GH.
- T-02Before-bed injection is the most important. Natural GH peaks during deep sleep.
- T-03Mix CJC and Ipamorelin in the same syringe for a single injection.
- T-04CJC-1295 no-DAC must be refrigerated post-reconstitution. Use within 4–6 weeks.
- T-05Monitor IGF-1 via blood test after 6–8 weeks to verify response.
- T-06Maintain protein intake (1.6–2g/kg) to support GH/IGF-1 driven synthesis.