CJC-1295 / Ipamorelin Protocol
Why Stack These Two
CJC-1295 (GHRH)
Baseline GH elevation
IPAMORELIN (GHRP)
Pulsatile GH spike
COMBINED EFFECT
~3–5× monotherapy
RECEPTOR PATHS
Different + synergistic
CJC-1295is a Growth Hormone Releasing Hormone (GHRH) analogue that elevates baseline GH secretion by amplifying the pituitary's GH output over several hours — the "foundation" of elevated GH throughout the day.
Ipamorelinis a Growth Hormone Releasing Peptide (GHRP) that triggers a clean, strong GH pulse from the pituitary without significantly raising cortisol or prolactin — the "spike" on top of CJC's baseline. GHRH analogues and GHRPs work on different receptors via different mechanisms, so combining them produces a GH pulse roughly 3–5× greater than either alone.
Dosing Protocol
| Time | Peptide | Dose | Notes |
|---|---|---|---|
| Before bed (fasted 2+ hrs) | CJC-1295 no-DAC | 100mcg | Same syringe as Ipamorelin |
| Before bed (fasted 2+ hrs) | Ipamorelin | 200mcg | Mix with CJC in same syringe |
| Optional: Pre-workout (fasted) | CJC-1295 no-DAC | 100mcg | Second pulse for advanced users |
| Optional: Pre-workout (fasted) | Ipamorelin | 200mcg | Second pulse for advanced users |
NOTE — Always inject fasted (min 2 hrs after food, 30–60 min before food). Insulin blunts GH release.
Cycle Structure
- C-01
Beginner — 6 weeks on / 2 off
Single bedtime injection only. 1× CJC + 1× Ipamorelin per day. Assess sleep quality, body composition.
- C-02
Intermediate — 8 weeks on / 4 off
Bedtime injection required, optional second pre-workout pulse. Expect more pronounced body composition changes.
- C-03
Advanced — 3 months on / 1 off
Two daily injections. Some users run longer cycles with lab monitoring of IGF-1 levels.
- C-04
DAC variant
CJC-1295 with DAC: inject once or twice weekly (half-life ~8 days). Ipamorelin still daily at bedtime.
What to Expect
| Period | Expected Effect |
|---|---|
| Week 1–2 | Improved sleep quality, deeper cycles, vivid dreams. Energy begins to improve. |
| Week 3–4 | Slight muscle fullness, reduction in soft fat (especially midsection). |
| Month 2 | More significant body composition. Muscle definition improves, recovery accelerates. |
| Month 3+ | Skin quality, reduced joint soreness, IGF-1 elevation if measured. |
Key Tips
- T-01Inject fasted — never within 2 hrs of eating. Insulin suppresses GH.
- T-02Before-bed injection is the most important — natural GH peaks during deep sleep.
- T-03Mix CJC and Ipamorelin in the same syringe for a single injection.
- T-04CJC-1295 no-DAC must be refrigerated post-reconstitution. Use within 4–6 weeks.
- T-05Monitor IGF-1 via blood test after 6–8 weeks to verify response.
- T-06Maintain protein intake (1.6–2g/kg) to support GH/IGF-1 driven synthesis.