In SURMOUNT-1, a 72-week phase 3 trial of 2,539 adults with obesity or overweight and no diabetes, body weight fell 15%, 19.5% and 20.9% on the 5, 10 and 15 mg tirzepatide arms, against 3.1% on placebo.
In the same trial, 4.3%, 7.1% and 6.2% of participants on the 5, 10 and 15 mg arms stopped treatment because of adverse events, against 2.6% on placebo.
In STEP 1, a 68-week phase 3 trial of 1,961 adults with obesity or overweight and no diabetes, body weight fell 14.9% on semaglutide 2.4 mg, against 2.4% on placebo. In SURMOUNT-5, a 72-week phase 3b trial of 751 adults with obesity and no type 2 diabetes that compared the two molecules directly, body weight fell 20.2% on tirzepatide against 13.7% on semaglutide, each at the maximum tolerated dose.
Trial averages describe the population studied under supervised conditions, not an individual. The class-wide adverse-event material is in the GLP-1 side effects guide, and none of it is medical advice.